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Similac Pro-Sensitive Vs Similac Pro-Total Comfort

Formula feeding our babies vs breastfeeding is always a debate. Both of them are acceptable and the choice is entirely up to you and whatever suits you and your baby’s physical health and mental health.

Whether you’re a mom who chooses formula feeding since birth or one who chose to switch from breastfeeding to formula feeding we can all agree that one of the most important things before buying the right formula is to do some research.

If you’re a mommy, daddy or carer who’s browsing through your formula feeding options you’re probably familiar with a very well known brand called Similac.

What is the difference between Similac Pro-Sensitive and Similac Pro-Total Comfort? Similac Pro-Sensitive contains intact milk protein, on the other hand, Similac Pro-Total Comfort contains 100% whey protein that has been partially hydrolyzed, this helps as an alternative to regular milk-based formulas and intact protein.

What’s the difference between Similac Sensitive and total comfort?

While both formulas seem to help infants with sensitive tummies Similac Pro-Total Comfort claims to act faster, hence the 1Day-less crying claims.

Similac Pro-Sensitive is designed for babies who suffer from gas or fussiness from feeding while Similac Pro-Total Comfort and its gentle formula have been designed to help those babies who have problems or intolerance to milk-based formulas and have constant problems with digestion sensitivity.

Similac Pro-Sensitive is available in 1.41-lb (638g) powder, 29.8-oz powder and 1-qt ready to feed. On the other hand, Similac Pro-Comfort is only available in 1.41-lb (638g) powder.

Some people claim that the special formula for sensitive tummies and easy to digest probiotics used on Similac Pro-Sensitive help soften stools.

Similac has different formulas to choose from. Two of them are Similac Pro-Total Comfort and Similac Pro-Sensitive. But among this beloved two choosing which one is the best can be difficult and the truth is the answer is subjective to your baby’s needs.

When an infant suffers from a sensitive tummy it’s logical we are going to try to do what’s best for them and choosing the right formula can definitely be a step towards that.

For parents of babies with digestion problems choosing what’s best can be a little intimidating, especially when you’re trying to navigate an unknown area.

Similac Pro-Sensitive Vs Similac Pro-Total Comfort

Thankfully, nowadays it’s very easy to find the right information to help us make the best decision. But before making that decision of choosing between Similac Pro-Total Comfort and Similac Pro-Sensitive we need to learn more about them.

Similac Pro-sensitive:

According to the official Similac website, The famous Pro-Sensitive formula is designed for fussiness and gas caused by lactose sensitivity. This formula contains 2’FL HMO for immune support. 2’FL means 2′-fucosyllactose and HMO stands for human milk oligosaccharides. 2’ FL is the most abundant human milk oligosaccharide found in breast milk.

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However, if you’re not familiar with these concepts there is nothing to fear, the 2’ FL found in Similac Pro-sensitive does not come from human milk, there is a fermentation process used to create it, which according to the Similac website is similar to the fermentation process used to create vitamins such as B2.

The 2’Fl found in Similac is structurally identical to the one found in human milk which makes this formula very appealing for those parents who didn’t choose to breastfeed but still want their babies to have a formula that is very close to breast milk.

Similac Pro-Sensitive does not contain artificial growth hormones. This formula also contains Lutein, Vitamin E and DHA all of which are important to the development of infants’ brains and eyes. The Pro-sensitive formula is not suitable for babies with galactosemia. It contains milk ingredients.

Similac Pro-Total Comfort:

According to Similac, the Pro-Total Comfort formula is their most gentle formula with 2’-FL HMO. Similac Pro-Total Comfort claims to have a unique blend of DHA and Lutein. Just like other Similac products, it doesn’t contain artificial growth products. This formula’s key feature is that it contains partially hydrolyzed protein for easy digestion.

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This particular formula claims to help ease the fussiness and gas faster or as they call it 1Day-less crying. In comparison with other formulas such as Enfamil NeuroPro, Similac Pro-Total Comfort makes 4 more 6-fl-oz bottles.

Thanks to the 2’FL HMO and partially hydrolyzed protein Similac Pro-Total Comfort is very similar to breast milk. An important note is that this formula is not suitable for infants or children with galactosemia.

Now you know what these two formulas are there’s no doubt that they sound like a very good option and you can understand why both of them are highly recommended, however, you might still be wondering which one is the best option for you and your infant. So let’s go more in debt.

Why is it important to choose the right formula milk?

One of the questions people often ask us is since they find out we are pregnant and a question that we also ask ourselves is how are we going to choose to feed our baby when they are born? Exclusively breastfeeding? Formula feeding? A combined diet (breastfeeding+formula).

You’re often going to be hearing things such as: “Breast is best!” And although we know breastfeeding can be very good and bring some benefits to mothers and babies many infants who are formula-fed are very healthy and can develop perfectly fine. That’s thanks to formula milk containing lots of the nutrients and vitamins that infants need.

Formula feeding has been a thing since the 1800s when it was first created, many years later the market is still growing strong, thanks to its popular demand and thanks to the brands that produce formula milk being able to create products that match our needs.

Doctors often recommend infants to have cow’s milk formula, thankfully, most formulas in the market are made from cow’s milk. If your infant presents a problem with a regular formula or cow’s milk formula, depending on the root of the problem your doctor might recommend a soy formula or a hydrolyzed formula that still contains cow’s milk but its proteins have been broken down.

Benefits of hydrolyzed formulas:

According to WebMD, many doctors recommend hydrolyzed-type formulas when the infant suffers from allergies. A hydrolyzed formula can be particularly good for a baby who suffers from milk protein allergy.

Hydrolyzed formulas contain cow’s milk protein that has been broken down so that babies with sensitive tummies can tolerate it.

Different formulas that contain the hydrolyzed title might have different descriptions such as: partially or extensively hydrolyzed. In the case of Similac Pro-Total Comfort, the formula is partially hydrolyzed. As the name suggests, extensively hydrolyzed formulas proteins are broken down, even more, this helps because the formula is then classified as hypoallergenic.

In some cases, infants who have been exclusively been given hydrolyzed formulas during the first year of their lives have shown improvement to their milk protein intolerance in later years. But always consult with your doctor before trying anything new because in some infants’ cases their intolerance might be more severe.

Pros and Cons

Features Similac Pro-Sensitive Similac Pro-Comfort
Calms fussiness and gas  
Designed for infants with persistent feeding issues  
Partially hydrolyzed protein for easy digestion  
Easy to digest gentle protein and probiotics  
Contains 2’ Fl HMO
Suitable for infants with galactosemia    
Suitable from birth
GMO Free
Palm oil free
Contains Lutein, DHA and Vitamin E
Contains Corn Syrup as one of the main ingredients  
Helps softens baby’s stool  
It’s more popular  
Has better reviews  
It’s more affordable    
It’s also available on a ready to feed presentation  

In summary, Similac is a respected brand and the Pro-Sensitive and Pro-Total Comfort formula seems to be getting only more popular. Similac Pro-Sensitive has some advantages, one of them is the different presentations such as the ready to feed bottle which makes things easier if you’re a person who’s constantly on the go with your little one.

The Pro-Sensitive might also be an easier transition for those babies who are moving from breastfeeding and for babies with minor feeding issues.

Although this doesn’t mean that Similac Pro-Total Comfort is not good, the Pro-Total Comfort formula could benefit a struggling infant and act quicker, if you have tried different milk formulas and the problem is still there the Pro-Total Comfort formula could be a solution.

Also, The Pro-Total Comfort formula does not contain corn syrup while Similac’s Pro-Sensitive does contain it as one of its main ingredients. Some parents might have a problem with this because of the sugar levels in corn syrup.

Both formulas have similarities and also things that make them different that’s why answering the question of which is better than the other is very difficult since at the end of the day it’s all a personal choice.

The most important thing to do is to have your baby’s needs in mind and to check that each formula has what you expect/want for your baby. Fortunately, both formulas are GMO-free and contain nutrients that are important for babies development through their first year of life.

NOTE: Before buying any product it’s recommendable to speak to your pediatrician first to have a complete understanding of your child’s dietary requirements.

When you decide to switch milk keep track of your babies’ behavior and their reaction to the new formula milk. Is there any improvement? Is their stool looking alright? Are they less irritated? If the answer for all of those is no you might want to reconsider the type of formula your baby is being fed and having a further discussion with your advisor.

Follow your health’s advisor recommendations and follow the instructions of preparation of the formula milk you have decided it’s the best for you.

More About Similac

The company that created Similac was founded in 1903; it were known as Moores and Ross Milk Company. Years later, in 1925 the company created the first commercial milk-based baby formula, Similac. Moores and Ross were innovators in the milk formula business, they were also the ones to create the first iron-fortified formula and the first liquid formula.

Since 1964 Ross and Milk united with Abbott laboratories.

Nowadays Similac is part of Abbott Nutrition and despite its changes, Similac still continues as one of the pioneers in the milk formula market. This happens thanks to

Similac providing confidence and delivering a quality product to both combined diet and formula feeding parents. Similac has a wide range of formulas to choose from depending on your children’s age, dietary requirements, and personal preferences. Similac contains different formula milk options such as non-GMO, soy, hypoallergenic, sensitive and organic formulas to name some.


Do I listen to people’s reviews?

As we previously mentioned both Similac formulas have an overall good rating system and positive reviews but there’s always going to be people who think otherwise. Remember what works for one person might not work for another. Reviews are personal opinion and you’re always allowed to try things and make your own conclusions.

Do I go for the cheapest one?

You’re welcome to try the most affordable option if you think it’s the most adequate option for you. Although have in mind that the price difference between the two is not significantly drastic.

Which one is closer to breastmilk?

Thankfully, both formulas contain a blend of DHA, Lutein and Vitamin E which are important ingredients found in breastmilk. There’s nothing that states than one is closer to breastmilk than the other. However, the Similac website states that The Pro-Advance is their closest to breastmilk.

Monica Lawrence

I’m Monica, a single mother who’s raising two beautiful angels. Here, I share helpful and creative articles and how-to’s for all the busy, multitasking moms.